I have this effect when I play games with a mouse, sooner or later I get a very strange mouse behavour. The mouse pointer is like sticking to the sides of the screen only going up and down very fast and you can't use it anymore. Always have to reboot.
It seems that this happens only on games where you have to use the keyboard in parallel for CTRL or CMD or ALT clicks. usually it happens after some minutes but you can force it a little bit with hard core clicking.
Im not sure if it happens on all games, I can reproduce on C&C and on Freddy Pharkas, but C&C is the easiest to reproduce because you always put the mouse on the edge of the screen for scrolling.
Others with this problem or even with a solution? I tried with different VHDs from @flynnsbit and @nml32.